Active substances of medical device

Pelargonium sidoides DC. – flowering plant originating from South Africa

To avoid negative impact of antibiotics and synthetic antiseptics, a set of natural biologically active compounds from P. sidoides was chosen as an alternative prevention and treatment option.

  • Lewu, F.B.; Grierson, D.S.; Afolayan, A.J. Extracts from Pelargonium sidoides. Inhibit the Growth of Bacteria and Fungi. Pharm. Biol. 2006, 44, 279–282, doi:10.1080/13880200600714137.
  • Lewu, F.B.; Grierson, D.S.; Afolayan, A.J. The leaves of Pelargonium sidoides may substitute for its roots in the treatment of bacterial infections. Biol. Conserv. 2006, 128, 582–584, doi:10.1016/J.BIOCON.2005.10.018.
  • Kayser, O.; Kolodziej, H. Antibacterial Activity of Extracts and Constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med. 1997, 63, 508–510, doi:10.1055/s-2006-957752.
  • Bereznoy, V.V; Riley, D.S.; Wassmer, G.; Heger, M. Efficacy of extract of Pelargonium sidoides in children with acute non-group A beta-hemolytic streptococcus tonsillopharyngitis: A randomized, double-blind, placebo-controlled trial. Altern. Ther. Health Med. 2003, 9, 68–79.
  • Bachert, C.; Schapowal, A.; Funk, P.; Kieser, M. Treatment of acute rhinosinusitis with the preparation from Pelargonium sidoides EPs 7630: A randomized, double-blind, placebo-controlled trial. Rhinology 2009, 47, 51–58.

Qualitative and quantitative analysis of Pelargonium sidoides root extract (PSRE) by HPLC


  • red brown to dark brown powder, sifted through 0.7 mm (25 mesh).
  • Extraction medium – 50%(m/m) Ethanol.
  • Solubility: methanol, ethanol,
Compounds determined in PSRE RT mg/g
1 Catechin 16.13 2.30
2 Epicatechin 19.17 0.30
3 Epigallocatechin 12.49 7.71
4 Epigallocatechin gallate 21.47 1.19
5 Gallic acid 8.17 0.84


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